GnRH Receptor
Gonadotropin releasing hormone receptor; GNRHR
The GnRH receptor (Gonadotropin-releasing hormone receptor, GNRHR) is a member of the rhodopsin-like G protein-coupled receptor (GPCR) family and consists of seven transmembrane helical domains connected via extra- and intra-cellular segments. GnRH receptor is located on the plasma membrane of gonadotrophs, pituitary cells that synthesize the gonadotrophins LH and FSH.
Mammalian type I and II GnRH receptors show differential ligand preference for GnRH-I (also named as LHRHR) and GnRH-II, respectively. All GnRH receptors activate the Gq/11 family of G proteins, which activate phospholipase C-catalyzed production of second messengers that activate protein kinase C (PKC). GnRH receptor activated by GnRH analogues stimulates the synthesis and release of LH and FSH. GnRH receptors can be used for the research of breast and prostate cancer, regulation of fertility, endometriosis and a range of other medical and veterinary uses.
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GnRH Receptor Related Products (161)
Related Products (161)
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Antibodies (3)
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sGnRH-A
0 ImagessGnRH-A is a salmon gonadotropin-releasing hormone (GnRH) analogue. sGnRH-A stimulates growth hormone secretion. sGnRH-A also can be used as an inducer of ovulation by artificial insemination.
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Threonyl-seryl-lysine
0 ImagesThreonyl-seryl-lysine, a bovine pineal antireproductive tripeptide, has antigonadotropic activity. Threonyl-seryl-lysine binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5.
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Goserelin-d7 TFA
0 ImagesCat. No.: HY-13673S2Synonyms: ICI 118630-d7 TFA
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(Des-Pyr1)-LHRH
0 Images(Des-Pyr1)-LHRH is a Polypeptide Internal Standard, identical to (Des-Pyr1)-GnRH, which can be identified through peptide screening. Peptide screening is a research tool that mainly collects active polypeptides via immunoassays. It can be applied to protein interaction, functional analysis, epitope screening, especially in the field of active molecule research and development. (Des-Pyr1)-LHRH can serve as an internal standard (ISTD) for mass spectrometry analysis.
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AG-045572
0 ImagesAG-045572 is a GnRH receptor antagonist with Kis of 6.0 nM and 3.8 nM for human and rat GnRH receptor, respectively. AG-045572 is metabolized by CYP3A and ressuppresses testosterone.
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GnRH-R antagonist 1
0 ImagesCat. No.: HY-151247CAS No.: 2826273-90-7GnRH-R antagonist 1 (compound 21a) is an orally safe and membrane-permeable GnRH-R antagonist with high binding affinity (IC50=0.57 nM) and potent in vitro antagonistic activity (IC50=2.18 nM). GnRH-R antagonist 1 can be used in studies of advanced prostate cancer and premature LH peaks preventing.
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Merigolix
0 ImagesCat. No.: HY-152856CAS No.: 1454272-94-6Merigolix is a potent gonadotrophin releasing hormone (GnRH) antagonist.
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Degarelix acetate hydrate
0 ImagesCat. No.: HY-16168BCAS No.: 934246-14-7Synonyms: FE 200486 acetate hydrateDegarelix acetate hydrate (FE 200486 acetate hydrate) is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR/LHRHR) antagonist. Degarelix acetate hydrate can be used for prostate cancer research.
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Teverelix
0 ImagesCat. No.: HY-105173CAS No.: 151272-78-5Synonyms: EP 24332
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Linzagolix choline
0 ImagesSynonyms: KLH-2109 choline; OBE-2109 cholineLinzagolix choline (KLH-2109 choline) is a non-peptide gonadotropin-releasing hormone (GnRH) antagonist with oral activity. Linzagolix choline inhibits the release of endogenous gonadotropins such as luteinizing hormone LH and follicle-stimulating hormone FSH by binding to the GnRH receptor within the pituitary gland. This inhibition results in a reduction in the production of sex hormones such as estrogen and progesterone, which in turn affects the course of sex hormone-dependent diseases. Linzagolix choline can be used in the study of sex hormone-dependent diseases such as endometriosis and uterine fibroids.
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YQGN-7
0 ImagesCat. No.: HY-P11265YQGN-7 is a targeted fluorescent probe for the gonadotropin-releasing hormone receptor (RnRHR). YQGN-7 exhibits high selectivity and affinity for breast cancer cells (KD = 217.8 nM). YQGN-7 achieves precise visualization of the primary and metastatic lesions of breast cancer by targeting the highly expressed GnRHR in tumor cells. YQGN-7 can be used in the research of breast cancer breast-conserving surgery (BCS).
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(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH
0 ImagesCat. No.: HY-P4564CAS No.: 1926163-38-3(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH). LHRH plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
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GnRH-R antagonist-3
0 ImagesCat. No.: HY-178419CAS No.: 666852-12-6GnRH-R antagonist-3 (Compound 37) is a Gonadotropin releasing hormone receptor (GnRH-R) antagonist with IC50s of 94 and 275 nM for rat and human GnRH-R, respectively. GnRH-R antagonist-3 can be used for hormone dependent diseases such as endometriosis, breast and prostate cancer research.
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Avorelin
0 ImagesCat. No.: HY-106138CAS No.: 140703-49-7Synonyms: Meterelin; MF 6001Avorelin (Meterelin) is a gonadotropin releasing hormone (GnRH) agonist. Avorelin can be used of the study of prostate cancer.
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GnRH Associated Peptide (25-53), human
0 ImagesCat. No.: HY-P3605CAS No.: 106061-19-2Synonyms: GAP (25-53), humanGnRH Associated Peptide (GAP) (25-53), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 25-53 fragment (hGAP-25-53), can be used as immunogen to generate antiseras including MC-1, MC-2, and MC-3. GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site.
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Ramorelix
0 ImagesCat. No.: HY-P2115CAS No.: 127932-90-5Ramorelix is a luteinizing-hormone-releasing hormone (LHRH) antagonist. Ramorelix can inhibit tumor progression in vivo. Ramorelix can be studied in anti-cancer research.
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Argtide
0 ImagesCat. No.: HY-P2067CAS No.: 138111-66-7Argtide is a luteinizing hormone-releasing hormone (LHRH) antagonist. Argtide is used in endometriosis and cancer-related research.
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Federelin
0 ImagesCat. No.: HY-P11278CAS No.: 57521-78-5Synonyms: Gonadorelin[6-D-Phe]; [D-Phe6]GnRHFederelin (Gonadorelin[6-D-Phe]) is a gonadotropin (GnRH) analog.
